Vanguard® crLyme: Chimeric Recombinant Vaccine Technology for Broad-Spectrum Protection Against Canine Lyme Disease

yme disease remains one of the most common health threats for dogs in the US. The disease is caused by Borrelia burgdorferi bacterial spirochetes that are transmitted to dogs through the bite of Ixodes spp. ticks. The disease threat can vary by location due to variability in opportunities for exposure to the infected carrier tick. For instance, a survey reported the prevalence of seropositive dogs in various regions. In Northeast states the regional mean was 11.6% (range of 7.1% in NY to 19.8% in MA) while in Midwest states the regional mean was 4.0% (<1% to 10.2% in WI). Canine Lyme disease manifests with arthritis-induced lameness, anorexia, fever, lethargy, lymphadenopathy and, in some cases, fatal glomerulonephritis.